Apoptosis and autophagy in polycystic kidney disease (PKD)
نویسندگان
چکیده
منابع مشابه
Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD).
Cyst expansion in polycystic kidney disease (PKD) results in localized hypoxia in the kidney that may activate hypoxia-inducible factor-1α (HIF-1α). HIF-1α and autophagy, a form of programmed cell repair, are induced by hypoxia. The purposes were to determine HIF-1α expression and autophagy in rat and mouse models of PKD. HIF-1α was detected by electrochemiluminescence. Autophagy was visualized...
متن کاملmTORC 1 / 2 and rapamycin in female Han : SPRD rats with polycystic 1 kidney disease ( PKD )
mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic 1 kidney disease (PKD). 2 3 Franck Belibi*, Kameswaran Ravichandran*, Iram Zafar*, Zhibin He and Charles L. 4 Edelstein. 5 6 Division of Renal Diseases and Hypertension, Univ. of Colorado at Denver and the 7 Health Sciences Center, Aurora, Colorado, USA 8 9 *Authors contributed equally to the study 10 11 12 Correspondence to Charles...
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BACKGROUND Short-term studies have demonstrated that rapamycin or everolimus treatment decreases cyst formation and improves renal function in animal models of polycystic kidney disease (PKD). Autosomal dominant polycystic kidney disease (ADPKD) patients would likely require life-long treatment with rapamycin. METHODS Male Han:SPRD rats with PKD (Cy/+) were treated with rapamycin (0.2 mg/kg/d...
متن کاملA New PKD-1 Mutation Discovered in a Black African Woman With Autosomal Polycystic Kidney Disease
Autosomal polycystic kidney disease (ADPKD) is a genetic disorder with two causal PKD-1 and PKD-2. Genetic studies have demonstrated an important allelic variability between patients but few data are known about genetic variants in African populations. We report a new mutation found in a 41-year old women with mild chronic kidney disease secondary to ADPKD. Molecular genetic testing found a del...
متن کاملa new pkd-1 mutation discovered in a black african woman with autosomal polycystic kidney disease
autosomal polycystic kidney disease (adpkd) is a genetic disorder with two causal pkd-1 and pkd-2. genetic studies have demonstrated an important allelic variability between patients but few data are known about genetic variants in african populations. we report a new mutation found in a 41-year old women with mild chronic kidney disease secondary to adpkd. molecular genetic testing found a del...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2020
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2019.109518